A nukleotidok és az aktinkötő fehérjék szerepe az aktin funkcionális konformációváltozásaiban
Türmer Katalin Erzsébet
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Actin is one of the main component in eukaryote cells which plays significant role in many cellular processes, like force-generation, maintenance of the shape of cells, celldivision cycle, and transport processes. Many structural investigations showed that the monomer actin (G-actin) consists of four subdomains, the internal structure of subdomains are stabilized by nucleotide, either ATP or ADP and a divalent cation (calcium or magnesium). The structure of subdomains is dynamic, as derived by several biophysical and structural studies; the subdomain might have different motional states depending on the bound cations and nucleotides. Site-specific cross-linking among F-actin monomers inhibits the motion and force generation in myosin. The ability of G-actin to reversible polymerize into long filaments is essential for many cellular functions.