High-dose radiotherapy procedures requiring precision, multimodal imaging

Abstract

In this dissertation, we studied the use of multimodality-based high-dose radiotherapy procedures in cervical and head and neck cancer. Our first aim was to present our experiences with the CovP SIB-N focusing on clinical outcomes and nodal volume changes measured on CBCT during treatment. Our results confirm an excellent 2-year clinical efficacy without nodal failures besides and minimal severe morbidity. During the evaluation of 650 CBCTs a volume-dependent regression could be observed which might allow for early dose adaptation strategies in the future. - Retrospective validation of coverage probability based simultaneous integrated nodal boost in locally advanced cervical cancer: a mono-institutional analysis Our second aim was to report on the pretreatment PET/MR based PET and MR- Diffusion weighted imaging (DWI) parameters (SUVmax, SULpeak, MTV, TLG, ADCmean) role in predicting outcome at HNSCC patients treated with single 18 F-FDG injection dual imaging acquisition PET/MR based chemoradiotherapy. Our finding implies a new perspective of HNSCC treatment planning (with single tracer injection dual imaging protocol) which will be a crutch for the diagnostic physicians to prescribe the best therapy patient tailored. - Predictive value of diffusion, glucose metabolism parameters of PET/MR in patients with head and neck squamous cell carcinoma treated with chemoradiotherapy.