A mikropartikulumok laboratóriumi diagnosztikája

Abstract

Microparticles were first described by Chargaff in 1946 as precipitable factors that accelerate thrombine formation in platelet-free plasma. Twenty years later, Wolf gave them the name ’platelet dust’ and discovered that they have the ability to produce thrombine after the ultracentrifugation of plasma. As a result of the development of measuring methods from the 90s onwards, our knowledge about ’platelet dust’ has broadened and deepened considerably. These particles have since been called microparticles (MP) and microvesicles (MV). It has become clear later that besides in vivo platelets, they may originate from other cells and that they can be detected not only in the circulating blood but also in other body fluids e.g. urine, cerebrospinal fluid, synovial fluid and saliva.