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Elérhetővé téve ekkor2019-12-04T09:32:15Z
Szerző Szélig Lívia
MTMTID:
10049459
Webcímhttp://pea.lib.pte.hu/handle/pea/23308
Az értekezés nyelveMagyar
Az értekezés címe az értekezés nyelvénGyulladásos és oxidatív stressz markerek vizsgálata égett és szeptikus betegekben
Az értekezés címe angolulInvestigation of Inflammation and Oxidative Stress Markers in Sepsis and Burn Injury
Absztrakt az értekezés nyelvénBesides injury to the skin, severe burn trauma may initiate pathophysiological processes and changes affecting the entire organism. Metabolic processes activated by stress and pain, and neuro-hormonal changes result in hyper-metabolism and consequently, a catabolic metabolism. The activation of the immune system causes a release of a large amount of inflammatory mediators. Pro-inflammatory cytokines play a key role in initiating SIRS. SIRS results in a life-threatening condition by causing multiple organ failure or dysfunction that pose a great challenge in terms of treatment and thus, necessitate special intensive therapy. Changes in surface markers accompanying leukocyte activation and migration show a characteristic pattern and play an important role in the initiation and development of the inflammatory reaction following burn injury. At present, hundreds of specific CD markers are known. They are known to be involved in immune processes, cellular connections and tissue differentiation. Adhesion molecules CD11a, CD11b, CD18 and CD49d have a significant role in leukocyte attachment and recruitment. CD14 a is a recognising molecule bound to the surface of monocytes and macrophages. Only few human data are available in the literature in connection with CD markers after burn trauma.
EgyetemPécsi Tudományegyetem
Doktori iskolaÁOK Klinikai Orvostudományok Doktori Iskola
TémavezetőCsontos Csaba


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