Porcvédelem és az ízületi porc pótlásának lehetőségei az ortopédiai gyakorlatban

Abstract

Full-thickness cartilage lesions in adults caused by mechanical injuries or diseases, are common problems in orthopedic surgery treating locomotor disorders. The mature cartilage is an avascular, bradytroph tissue, therefore the cartilage nutrition is only available via diffusion from the synovial fluid, and the chondrocytes show slow metabolic activity. The articular cartilage is vulnerable due to its special position, the numerous forces reaching the chondral surface and the intensive mechanical strain. In inverse proportion to its vulnerability, the regenerative healing capacity of articular cartilage is strongly restricted. Once a cartilage lesion occurs on a weight-bearing surface of a joint, it increases and the whole progress extends not only in size but also in depths reaching the subchondral bony surface resulting in osteoarthritis. The cartilage lesions predominantly affect the weight-bearing articular surfaces of joints, therefore the development of chondral or osteochondral defects is a great burden to locomotor patients.