Synthesis of 1,4-diazine-fused and phosphorus containing stable nitroxide free radicals

Abstract

The aim of my PhD-work at the University of Pécs, Institute of Organic and Medicinal Chemistry was to develop new selective syntheses and methods to access new nitroxide derivatives, suitable for biological applications. The results were published in 5 peer-reviewed papers on the synthesis and characterization of new stable nitroxide compounds and are summarised in the following main topics: 1. Syntheses of 1,4-diazine- and an imidazole-fused pyrroline nitroxide. 2. Syntheses of new pyrroline and piperidine nitroxide phosphonate esters by the well established methods and further transformations of the new products. 3. Syntheses of paramagnetic phospholene oxide, diphenyl-pyrroline nitroxide phosphine and its phosphonum salt